The second-to-last undergraduate genome paper is out. Curtobacterium flaccumfaciens by Jennifer Flanagan.
Seminar at #UCDavis: Michelle Smith, Wash U, “From the clinic to the bench: Using gnotobiotic mouse models uncovers a role for the gut microbiota in malnutrition”
Michelle Smith from Wash U in St. Louis
Meyer Hall, Room 1138. Noon. 5/16/2013
"From the clinic to the bench: Using gnotobiotic mouse models uncovers
a role for the gut microbiota in malnutrition"
Abstract from recent Science paper:
Kwashiorkor, an enigmatic form of severe acute malnutrition, is the
consequence of inadequate nutrient intake plus additional
environmental insults. To investigate the role of the gut microbiome,
we studied 317 Malawian twin pairs during the first 3 years of life.
During this time, half of the twin pairs remained well nourished,
whereas 43% became discordant, and 7% manifested concordance for acute
malnutrition. Both children in twin pairs discordant for kwashiorkor
were treated with a peanut-based, ready-to-use therapeutic food
(RUTF). Time-series metagenomic studies revealed that RUTF produced a
transient maturation of metabolic functions in kwashiorkor gut
microbiomes that regressed when administration of RUTF was stopped.
Previously frozen fecal communities from several discordant pairs were
each transplanted into gnotobiotic mice. The combination of Malawian
diet and kwashiorkor microbiome produced marked weight loss in
recipient mice, accompanied by perturbations in amino acid,
carbohydrate, and intermediary metabolism that were only transiently
ameliorated with RUTF. These findings implicate the gut microbiome as
a causal factor in kwashiorkor.
Seminar 5/14 4PM: Gideon Bradburd Disentangling effects of geographic & ecological isolation on genetic differentiation
CPB Seminar Series: Spring 2013
When: Tuesdays, 4:10 – 5:30PM
Where: 1022 Life Sciences Building
May 14: Gideon Bradburd, Graduate Student
Center for Population Biology, UC Davis
Title: “Disentangling the effects of geographic and ecological isolation on genetic differentiation”
Seven months after starting the sample collections we finally submitted our pooled 16S library today for sequencing. We have somewhere around 90 samples from a few different types of aquariums and our community succession experiment. Now time for everyone to learn QIIME!
The days of this blog are numbered… There’s only a couple more papers to come out (both accepted) and then this project will be officially completed! I’ll write a summary and reflections on the whole process at that time.
Meanwhile, congrats to Jessica and Amanda whose papers came out this week:
Jessica’s Kocuria paper
Amanda’s Dietzia paper
I’m sitting here in the lab looking at our google doc and it’s looking pretty good! We only have a few final dilutions to do and we’ll be on our way to sequencing! I’m waiting for David to come back from lunch so he can update me on the next steps.
I’m excited for what’s to come!
10AM at #UCDavis – David Botstein “Coordination of growth rates, stress response & metabolic activity in yeast”
Department of Microbiology and Molecular Genetics
*Note the special time and day
Dr. David Botstein
(Anthony B. Evnin Professor of Genomics)
"Coordination of Growth Rate, Stress Response and Metabolic Activity in Yeast"
Tuesday, May 7, 2013
1022 Life Sciences
We will have our weekly lab meeting this week from 1:30 to 3pm in room 4202 of the Genome Center.
Dongying Wu is presenting.